Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.

AIMS: We studied the relationship between myofilament Ca(2+) sensitivity and troponin I (TnI) phosphorylation by protein kinase A at serines 22/23 in human heart troponin isolated from donor hearts and from myectomy samples from patients with hypertrophic obstructive cardiomyopathy (HOCM). METHODS A...

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Bibliographic Details
Main Authors:	Bayliss, C, Jacques, A, Leung, M, Ward, D, Redwood, C, Gallon, C, Copeland, O, McKenna, W, Dos Remedios, C, Marston, S, Messer, A
Format:	Journal article
Language:	English
Published:	2013

Myofibrillar Ca(2+) sensitivity is uncoupled from troponin I phosphorylation in hypertrophic obstructive cardiomyopathy due to abnormal troponin T.

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