NPC1 regulates ER contacts with endocytic organelles to mediate cholesterol egress

Transport of dietary cholesterol from endocytic organelles to the endoplasmic reticulum (ER) is essential for cholesterol homoeostasis, but the mechanism and regulation of this transport remains poorly defined. Membrane contact sites (MCS), microdomains of close membrane apposition, are gaining atte...

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Bibliographic Details
Main Authors: Höglinger, D, Burgoyne, T, Sanchez-Heras, E, Hartwig, P, Colaco, A, Newton, J, Futter, C, Spiegel, S, Platt, F, Eden, E
Format: Journal article
Language:English
Published: Springer Nature 2019