The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.

Mutations in the adenomatous polyposis coli (APC) gene are the basis of familial adenomatous polyposis and the majority of sporadic colorectal cancer. APC is expressed in a wide variety of tissues, interacts with the cytoskeleton, is involved in regulating levels of beta-catenin and, most recently,...

Бүрэн тодорхойлолт

Номзүйн дэлгэрэнгүй
Үндсэн зохиолчид:	Sieber, O, Tomlinson, I, Lamlum, H
Формат:	Journal article
Хэл сонгох:	English
Хэвлэсэн:	2000

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Modeling APC mutagenesis and familial adenomatous polyposis using human iPS cells.
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Ubiquitous neurocognitive dysfunction in familial adenomatous polyposis: proof-of-concept of the role of APC protein in neurocognitive function
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Identification of mutation in 3'-end of exon 15 of APC gene in familial adenomatous polyposis patients
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