Tumor imaging using radiolabelled matrix metalloproteinase-activated anthrax proteins

<p><strong>Purpose:</strong> Increased activity of matrix metalloproteinases (MMPs) is associated with worse prognosis in different cancer types. The protective antigen (PA-WT) of the binary anthrax lethal toxin was modified to form a pore in cell membranes only when cleaved by MMP...

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Detalhes bibliográficos
Principais autores: Xavier, M, Liu, S, Bugge, T, Baguna-Torres, J, Mosley, M, Hopkins, S, Allen, P, Berridge, G, Vendrell, I, Fischer, R, Kersemans, V, Smart, S, Leppla, S, Cornelissen, B
Formato: Journal article
Publicado em: Society of Nuclear Medicine and Molecular Imaging 2019