The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia
Osteoclast-mediated bone resorption is enhanced in the hypoxic microenvironment of diseases including rheumatoid arthritis and bone metastatic cancer. This increased resorption is driven by the hypoxia-inducible transcription factor, HIF. ADORA2b is a HIF-responsive gene that is upregulated in hypox...
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Hylonome
2018
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