The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia
Osteoclast-mediated bone resorption is enhanced in the hypoxic microenvironment of diseases including rheumatoid arthritis and bone metastatic cancer. This increased resorption is driven by the hypoxia-inducible transcription factor, HIF. ADORA2b is a HIF-responsive gene that is upregulated in hypox...
| Main Author: | |
|---|---|
| Format: | Conference item |
| Published: |
Hylonome
2018
|
| _version_ | 1797073775559180288 |
|---|---|
| author | Knowles, H |
| author_facet | Knowles, H |
| author_sort | Knowles, H |
| collection | OXFORD |
| description | Osteoclast-mediated bone resorption is enhanced in the hypoxic microenvironment of diseases including rheumatoid arthritis and bone metastatic cancer. This increased resorption is driven by the hypoxia-inducible transcription factor, HIF. ADORA2b is a HIF-responsive gene that is upregulated in hypoxic osteoclasts. ADORA2b is only functional in hypoxia or inflammatory conditions, as only then are activating extracellular concentrations of adenosine achieved by hydrolysis of extracellular ATP. Given the increasing interest in musculoskeletal effects of extracellular ATP, we investigated whether ADORA2b plays a role in osteoclast-mediated resorption of bone. |
| first_indexed | 2024-03-06T23:26:53Z |
| format | Conference item |
| id | oxford-uuid:6aa9460d-7e41-4ebf-9222-232edebb12d4 |
| institution | University of Oxford |
| last_indexed | 2024-03-06T23:26:53Z |
| publishDate | 2018 |
| publisher | Hylonome |
| record_format | dspace |
| spelling | oxford-uuid:6aa9460d-7e41-4ebf-9222-232edebb12d42022-03-26T18:58:58ZThe adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxiaConference itemhttp://purl.org/coar/resource_type/c_5794uuid:6aa9460d-7e41-4ebf-9222-232edebb12d4Symplectic Elements at OxfordHylonome2018Knowles, HOsteoclast-mediated bone resorption is enhanced in the hypoxic microenvironment of diseases including rheumatoid arthritis and bone metastatic cancer. This increased resorption is driven by the hypoxia-inducible transcription factor, HIF. ADORA2b is a HIF-responsive gene that is upregulated in hypoxic osteoclasts. ADORA2b is only functional in hypoxia or inflammatory conditions, as only then are activating extracellular concentrations of adenosine achieved by hydrolysis of extracellular ATP. Given the increasing interest in musculoskeletal effects of extracellular ATP, we investigated whether ADORA2b plays a role in osteoclast-mediated resorption of bone. |
| spellingShingle | Knowles, H The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia |
| title | The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia |
| title_full | The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia |
| title_fullStr | The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia |
| title_full_unstemmed | The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia |
| title_short | The adenosine A2B receptor (ADORA2B) drives osteoclast-mediated bone resorption in hypoxia |
| title_sort | adenosine a2b receptor adora2b drives osteoclast mediated bone resorption in hypoxia |
| work_keys_str_mv | AT knowlesh theadenosinea2breceptoradora2bdrivesosteoclastmediatedboneresorptioninhypoxia AT knowlesh adenosinea2breceptoradora2bdrivesosteoclastmediatedboneresorptioninhypoxia |