Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

Show other versions (1)

Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs) to be capable of inhibiting Cryptosporidium parvum at low micromolar concentrations in infected MDCK cells. Predictably, the mechanism of action is b...

Full description

Bibliographic Details
Main Authors: Artz, J, Dunford, J, Arrowood, M, Dong, A, Chruszcz, M, Kavanagh, K, Minor, W, Russell, R, Ebetino, F, Oppermann, U, Hui, R
Format: Journal article
Language:English
Published: 2008
Subjects:
Dimethylallyltranstransferase
Fluorescent Antibody Technique
Cryptosporidiosis
Models, Molecular
Chromatography, Liquid
Crystallography, X-Ray
Diphosphonates
Anti-Infective Agents
pharmacology
therapeutic use
enzymology
antagonists and inhibitors
Cattle
Cells, Cultured
Molecular Structure
drug therapy
Inhibitory Concentration 50
metabolism
Cryptosporidium parvum
drug effects
Protein Prenylation

Similar Items