Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

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Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs) to be capable of inhibiting Cryptosporidium parvum at low micromolar concentrations in infected MDCK cells. Predictably, the mechanism of action is b...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron:	Artz, J, Dunford, J, Arrowood, M, Dong, A, Chruszcz, M, Kavanagh, K, Minor, W, Russell, R, Ebetino, F, Oppermann, U, Hui, R
Fformat:	Journal article
Iaith:	English
Cyhoeddwyd:	2008
Pynciau:	Dimethylallyltranstransferase Fluorescent Antibody Technique Cryptosporidiosis Models, Molecular Chromatography, Liquid Crystallography, X-Ray Diphosphonates Anti-Infective Agents pharmacology therapeutic use enzymology antagonists and inhibitors Cattle Cells, Cultured Molecular Structure drug therapy Inhibitory Concentration 50 metabolism Cryptosporidium parvum drug effects Protein Prenylation

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