Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

अन्य संस्करण दिखाएं (1)

Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs) to be capable of inhibiting Cryptosporidium parvum at low micromolar concentrations in infected MDCK cells. Predictably, the mechanism of action is b...

पूर्ण विवरण

ग्रंथसूची विवरण
मुख्य लेखकों:	Artz, J, Dunford, J, Arrowood, M, Dong, A, Chruszcz, M, Kavanagh, K, Minor, W, Russell, R, Ebetino, F, Oppermann, U, Hui, R
स्वरूप:	Journal article
भाषा:	English
प्रकाशित:	2008
विषय:	Dimethylallyltranstransferase Fluorescent Antibody Technique Cryptosporidiosis Models, Molecular Chromatography, Liquid Crystallography, X-Ray Diphosphonates Anti-Infective Agents pharmacology therapeutic use enzymology antagonists and inhibitors Cattle Cells, Cultured Molecular Structure drug therapy Inhibitory Concentration 50 metabolism Cryptosporidium parvum drug effects Protein Prenylation

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