Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

Cryptosporidiosis is a neglected disease without a wholly effective drug. We present a study demonstrating nitrogen-containing bisphosphonates (N-BPs) to be capable of inhibiting Cryptosporidium parvum at low micromolar concentrations in infected MDCK cells. Predictably, the mechanism of action is b...

Полное описание

Библиографические подробности
Главные авторы:	Artz, J, Dunford, J, Arrowood, M, Dong, A, Chruszcz, M, Kavanagh, K, Minor, W, Russell, R, Ebetino, F, Oppermann, U, Hui, R
Формат:	Journal article
Язык:	English
Опубликовано:	2008
Предметы:	Dimethylallyltranstransferase Fluorescent Antibody Technique Cryptosporidiosis Models, Molecular Chromatography, Liquid Crystallography, X-Ray Diphosphonates Anti-Infective Agents pharmacology therapeutic use enzymology antagonists and inhibitors Cattle Cells, Cultured Molecular Structure drug therapy Inhibitory Concentration 50 metabolism Cryptosporidium parvum drug effects Protein Prenylation

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. по Artz, J, Dunford, J, Arrowood, M, Dong, A, Chruszcz, M, Kavanagh, K, Minor, W, Russell, R, Ebetino, F, Oppermann, U, Hui, R

Опубликовано 2008

Journal article

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis

Targeting a uniquely nonspecific prenyl synthase with bisphosphonates to combat cryptosporidiosis. по Artz, J, Dunford, J, Arrowood, M, Dong, A, Chruszcz, M, Kavanagh, K, Minor, W, Russell, R, Ebetino, F, Oppermann, U, Hui, R

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