Enhancement of morphine analgesia and prevention of morphine tolerance in the rat by the cholecystokinin antagonist L-364,718.

The potent and selective non-peptide cholecystokinin (CCK) antagonist L-364,718 (0.5-2.0 mg/kg s.c.) enhanced the analgesia induced by acute morphine treatment in the rat tail flick test. Chronic treatment with L-364,718 (1.0 mg/kg) prevented the development of tolerance to morphine analgesia (after...

وصف كامل

التفاصيل البيبلوغرافية
المؤلفون الرئيسيون: Dourish, C, Hawley, D, Iversen, S
التنسيق: Journal article
اللغة:English
منشور في: 1988