The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity.

There are three prolyl hydroxylases (PHD1, 2 and 3) that regulate the hypoxia-inducible factors (HIFs), the master transcriptional regulators that respond to changes in intracellular O(2) tension. In high O(2) tension (normoxia) the PHDs hydroxylate two conserved proline residues on HIF-1α, which le...

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Bibliographic Details
Main Authors: Foxler, D, Bridge, K, James, V, Webb, T, Mee, M, Wong, S, Feng, Y, Constantin-Teodosiu, D, Petursdottir, T, Bjornsson, J, Ingvarsson, S, Ratcliffe, P, Longmore, G, Sharp, T
Format: Journal article
Language:English
Published: 2012

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