Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.

CD8(+) cytotoxic T lymphocytes (CTL) are key determinants of immunity to intracellular pathogens and neoplastic cells. Recognition of specific antigens in the form of peptide-MHC class I complexes (pMHCI) presented on the target cell surface is mediated by T cell receptor (TCR) engagement. The CD8 c...

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Détails bibliographiques
Auteurs principaux:	Wooldridge, L, Lissina, A, Vernazza, J, Gostick, E, Laugel, B, Hutchinson, S, Mirza, F, Dunbar, P, Boulter, J, Glick, M, Cerundolo, V, van den Berg, H, Price, D, Sewell, A
Format:	Journal article
Langue:	English
Publié:	2007

Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.

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