Enhanced immunogenicity of CTL antigens through mutation of the CD8 binding MHC class I invariant region.

Míreanna comhchosúla

• Anti-CD8 antibodies can inhibit or enhance peptide-MHC class I (pMHCI) multimer binding: this is paralleled by their effects on CTL activation and occurs in the absence of an interaction between pMHCI and CD8 on the cell surface.
  de réir: Wooldridge, L, et al.
  Foilsithe / Cruthaithe: (2003)
• High avidity antigen-specific CTL identified by CD8-independent tetramer staining.
  de réir: Choi, E, et al.
  Foilsithe / Cruthaithe: (2003)
• Anti-coreceptor antibodies profoundly affect staining with peptide-MHC class I and class II tetramers.
  de réir: Wooldridge, L, et al.
  Foilsithe / Cruthaithe: (2006)
• Specificity of CTL interactions with peptide-MHC class I tetrameric complexes is temperature dependent.
  de réir: Whelan, J, et al.
  Foilsithe / Cruthaithe: (1999)
• A novel approach to antigen-specific deletion of CTL with minimal cellular activation using alpha3 domain mutants of MHC class I/peptide complex.
  de réir: Xu, X, et al.
  Foilsithe / Cruthaithe: (2001)