Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation

Increased proinsulin relative to insulin levels have been associated with subclinical atherosclerosis (measured by carotid intima-media thickness (cIMT)) and are predictive of future cardiovascular disease (CVD), independently of established risk factors. The mechanisms linking proinsulin to atheros...

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Bibliographic Details
Main Authors: Strawbridge, RJ, Silveira, A, Hoed, MD, Gustafsson, S, Luan, J, Rybin, D, Dupuis, J, Li-Gao, R, Kavousi, M, Dehghan, A, Haljas, K, Lahti, J, Gådin, JR, Bäcklund, A, de Faire, U, Gertow, K, Giral, P, Goel, A, Humphries, SE, Kurl, S, Langenberg, C, Lannfelt, LL, Lind, L, Lindgren, CCM, Mannarino, E, Mook-Kanamori, DO, Morris, AP, de Mutsert, R, Rauramaa, R, Saliba-Gustafsson, P, Sennblad, B, Smit, AJ, Syvänen, AC, Tremoli, E, Veglia, F, Zethelius, B, Björck, HM, Eriksson, JG, Hofman, A, Franco, OH, Watkins, H, Jukema, JW, Florez, JC, Wareham, NJ, Meigs, JB, Ingelsson, E, Baldassarre, D, Hamsten, A
Format: Journal article
Language:English
Published: Elsevier 2017

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