Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.

Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer.

Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and replication. Using pooled next-generation sequencing of 507 genes impl...

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Détails bibliographiques
Auteurs principaux: Ruark, E, Snape, K, Humburg, P, Loveday, C, Bajrami, I, Brough, R, Rodrigues, D, Renwick, A, Seal, S, Ramsay, E, Duarte, S, Rivas, M, Warren-Perry, M, Zachariou, A, Campion-Flora, A, Hanks, S, Murray, A, Ansari Pour, N, Douglas, J, Gregory, L, Rimmer, A, Walker, N, Yang, T, Adlard, J, Barwell, J
Format: Journal article
Langue:English
Publié: 2013

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