Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo.
The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus. In this study, we show that LEF1 and TCF7 (TCF-1)...
| Main Authors: | , , , , , |
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| Format: | Journal article |
| Jezik: | English |
| Izdano: |
2006
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| _version_ | 1826277458406539264 |
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| author | Willinger, T Freeman, T Herbert, M Hasegawa, H Mcmichael, A Callan, M |
| author_facet | Willinger, T Freeman, T Herbert, M Hasegawa, H Mcmichael, A Callan, M |
| author_sort | Willinger, T |
| collection | OXFORD |
| description | The transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus. In this study, we show that LEF1 and TCF7 (TCF-1) are not only expressed in thymocytes, but also in mature T cells. Our data demonstrate that Ag encounter in vivo and engagement of the TCR or IL-15 receptor in vitro leads to the down-regulation of LEF1 and TCF7 (TCF-1) expression in human naive CD8 T cells. We further show that resting T cells preferentially express inhibitory LEF1 and TCF7 (TCF-1) isoforms and that T cell activation changes the isoform balance in favor of stimulatory TCF7 (TCF-1) isoforms. Altogether, our study suggests that proteins involved in the WNT signaling pathway not only regulate T cell development, but also peripheral T cell differentiation. |
| first_indexed | 2024-03-06T23:29:12Z |
| format | Journal article |
| id | oxford-uuid:6b6dc6d7-d00f-404f-a97c-8dc8cfbc548d |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:29:12Z |
| publishDate | 2006 |
| record_format | dspace |
| spelling | oxford-uuid:6b6dc6d7-d00f-404f-a97c-8dc8cfbc548d2022-03-26T19:04:00ZHuman naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6b6dc6d7-d00f-404f-a97c-8dc8cfbc548dEnglishSymplectic Elements at Oxford2006Willinger, TFreeman, THerbert, MHasegawa, HMcmichael, ACallan, MThe transcription factors lymphoid enhancer binding factor 1 (LEF1) and transcription factor 7 (TCF7) (T cell factor-1 (TCF-1)) are downstream effectors of the WNT signaling pathway, which is a critical regulator of T cell development in the thymus. In this study, we show that LEF1 and TCF7 (TCF-1) are not only expressed in thymocytes, but also in mature T cells. Our data demonstrate that Ag encounter in vivo and engagement of the TCR or IL-15 receptor in vitro leads to the down-regulation of LEF1 and TCF7 (TCF-1) expression in human naive CD8 T cells. We further show that resting T cells preferentially express inhibitory LEF1 and TCF7 (TCF-1) isoforms and that T cell activation changes the isoform balance in favor of stimulatory TCF7 (TCF-1) isoforms. Altogether, our study suggests that proteins involved in the WNT signaling pathway not only regulate T cell development, but also peripheral T cell differentiation. |
| spellingShingle | Willinger, T Freeman, T Herbert, M Hasegawa, H Mcmichael, A Callan, M Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. |
| title | Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. |
| title_full | Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. |
| title_fullStr | Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. |
| title_full_unstemmed | Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. |
| title_short | Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo. |
| title_sort | human naive cd8 t cells down regulate expression of the wnt pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 t cell factor 1 following antigen encounter in vitro and in vivo |
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