Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons

The GLIS family zinc finger 3 isoform (GLIS3) is a risk gene for Type 1 and Type 2 diabetes, glaucoma and Alzheimer's disease endophenotype. We identified GLIS3 binding sites in insulin secreting cells (INS1) (FDR q<0.05; enrichment range 1.40-9.11 fold) sharing the motif wrGTTCCCArTAGs,...

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Bibliographic Details
Main Authors:	Calderari, S, Ria, M, Gérard, C, Nogueira, T, Villate, O, Collins, S, Neil, H, Gervasi, N, Hue, C, Suarez-Zamorano, N, Prado, C, Cnop, M, Bihoreau, M, Kaisaki, P, Cazier, J, Julier, C, Lathrop, M, Werner, M, Eizirik, D, Gauguier, D
Format:	Journal article
Language:	English
Published:	Elsevier 2018

Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons

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