Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons

Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons

The GLIS family zinc finger 3 isoform (GLIS3) is a risk gene for Type 1 and Type 2 diabetes, glaucoma and Alzheimer's disease endophenotype. We identified GLIS3 binding sites in insulin secreting cells (INS1) (FDR q<0.05; enrichment range 1.40-9.11 fold) sharing the motif wrGTTCCCArTAGs,...

Cur síos iomlán

Sonraí bibleagrafaíochta
Príomhchruthaitheoirí:	Calderari, S, Ria, M, Gérard, C, Nogueira, T, Villate, O, Collins, S, Neil, H, Gervasi, N, Hue, C, Suarez-Zamorano, N, Prado, C, Cnop, M, Bihoreau, M, Kaisaki, P, Cazier, J, Julier, C, Lathrop, M, Werner, M, Eizirik, D, Gauguier, D
Formáid:	Journal article
Teanga:	English
Foilsithe / Cruthaithe:	Elsevier 2018

Míreanna comhchosúla

Transcriptome Profiling in Rat Inbred Strains and Experimental Cross Reveals Discrepant Genetic Architecture of Genome-Wide Gene Expression.
de réir: Kaisaki, P, et al.
Foilsithe / Cruthaithe: (2016)

GLIS3, a susceptibility gene for type 1 and type 2 diabetes, modulates pancreatic beta cell apoptosis via regulation of a splice variant of the BH3-only protein Bim.
de réir: Tatiane C Nogueira, et al.
Foilsithe / Cruthaithe: (2013-05-01)

Genetic cartography of gene expression in white adipose tissue in the GK rat
de réir: Dubois, S, et al.
Foilsithe / Cruthaithe: (2011)

Report on rat chromosome 4
de réir: Gauguier, D, et al.
Foilsithe / Cruthaithe: (1999)

Detailed comparative gene map of rat chromosome 1 with mouse and human genomes and physical mapping of an evolutionary chromosomal breakpoint.
de réir: Kaisaki, P, et al.
Foilsithe / Cruthaithe: (2000)

Linkage and physical mapping of rat microsatellites derived from minisatellite loci.
de réir: Giraudeau, F, et al.
Foilsithe / Cruthaithe: (1999)

Construction of congenic lines for the locus Nidd/gk1 controlling glucose tolerance in the GK rat.
de réir: Wallis, R, et al.
Foilsithe / Cruthaithe: (1999)

First evidence of Paraheligmonina gracilis and Hymenolepis sulcata among fat dormice (Glis glis L.) from Croatia
de réir: Konjević D., et al.
Foilsithe / Cruthaithe: (2007-03-01)

Problem ochrony gatunku popielicy (Glis glis L.) w Polsce
de réir: Magdalena Klaudia Terlecka
Foilsithe / Cruthaithe: (2010-06-01)

Mapping diabetes QTL in an intercross derived from a congenic strain of the Brown Norway and Goto-Kakizaki rats.
de réir: Collins, S, et al.
Foilsithe / Cruthaithe: (2006)

A high-resolution consensus linkage map of the rat, integrating radiation hybrid and genetic maps.
de réir: Bihoreau, M, et al.
Foilsithe / Cruthaithe: (2001)

Regulation of microARN expression deteremined by systematic sequencing in obesity induced by a diet rich in fat
de réir: Diawara, M, et al.
Foilsithe / Cruthaithe: (2012)

Morphological parameters of the fat dormouse (Glis glis L.) in the forests of Gorski kotar
de réir: Josip Margaletić, et al.
Foilsithe / Cruthaithe: (2011-04-01)

Pathophysiological, genetic and gene expression features of a novel rodent model of the cardio-metabolic syndrome.
de réir: Wallis, R, et al.
Foilsithe / Cruthaithe: (2008)

Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome.
de réir: Wilder, S, et al.
Foilsithe / Cruthaithe: (2004)

Integration of the rat recombination and EST maps in the rat genomic sequence and comparative mapping analysis with the mouse genome
de réir: Wilder, S, et al.
Foilsithe / Cruthaithe: (2004)

Enhanced insulin secretion and cholesterol metabolism in congenic strains of the spontaneously diabetic (Type 2) Goto Kakizaki rat are controlled by independent genetic loci in rat chromosome 8.
de réir: Wallis, R, et al.
Foilsithe / Cruthaithe: (2004)

Finds of the fat dormouse (Glis glis) in cave-type shelters in the Middle Dnister Region
de réir: Oleksandr Vikyrchak, et al.
Foilsithe / Cruthaithe: (2020-07-01)

The European edible dormouse (Glis glis) in the territory of Bilsk Archaeological Complex (Poltava Oblast)
de réir: Vladyslav Bondarenko, et al.
Foilsithe / Cruthaithe: (2022-03-01)

Broad-ranging natural metabotype variation drives physiological plasticity in healthy control inbred rat strains.
de réir: Pontoizeau, C, et al.
Foilsithe / Cruthaithe: (2011)

Genetic control of differential acetylation in diabetic rats
de réir: Kaisaki, P, et al.
Foilsithe / Cruthaithe: (2014)

Complete genome searches for quantitative trait loci controlling blood pressure and related traits in four segregating populations derived from Dahl hypertensive rats.
de réir: Kato, N, et al.
Foilsithe / Cruthaithe: (1999)

Genomic organization and mutation screening of the human ortholog of Pkdr1 associated with polycystic kidney disease in the rat.
de réir: Kaisaki, P, et al.
Foilsithe / Cruthaithe: (2008)

Fatty Acid Composition of <i>M. Biceps Femoris</i> of Edible Dormouse (<i>Glis glis</i> L.)
de réir: Lana Pađen, et al.
Foilsithe / Cruthaithe: (2022-11-01)

A case study of the edible dormouse (Glis glis: Gliridae, Rodentia) biology using nestboxes
de réir: Viktoria A. Vekhnik, et al.
Foilsithe / Cruthaithe: (2018-07-01)

[Novel tools for chromosomal mapping and identification of genes underlying complex traits in the rat].
de réir: Gauguier, D, et al.
Foilsithe / Cruthaithe: (2008)

Report on rat chromosome 15
de réir: Bihoreau, M, et al.
Foilsithe / Cruthaithe: (1999)

Comparative analysis of methods for gene transcription profiling data derived from different microarray technologies in rat and mouse models of diabetes.
de réir: Wilder, S, et al.
Foilsithe / Cruthaithe: (2009)

Aryl hydrocarbon receptor nuclear translocator-like (BMAL1) is associated with susceptibility to hypertension and type 2 diabetes.
de réir: Woon, P, et al.
Foilsithe / Cruthaithe: (2007)

A gene map of the rat derived from linkage analysis and related regions in the mouse and human genomes.
de réir: Gauguier, D, et al.
Foilsithe / Cruthaithe: (1999)

Polygenic control of idiopathic generalized epilepsy phenotypes in the genetic absence rats from Strasbourg (GAERS).
de réir: Rudolf, G, et al.
Foilsithe / Cruthaithe: (2004)

Parasites, Bacteria and Viruses of the Edible Dormouse <i>Glis glis</i> (Rodentia: Gliridae) in the Western Palaearctic
de réir: Alexander A. Kirillov, et al.
Foilsithe / Cruthaithe: (2022-07-01)

Quantitative trait locus dissection in congenic strains of the Goto-Kakizaki rat identifies a region conserved with diabetes loci in human chromosome 1q.
de réir: Wallace, K, et al.
Foilsithe / Cruthaithe: (2004)

Pleistocene edible dormice (Rodentia Mammalia) from Slovenia, and their relations to the present day Glis glis (Linnaeus 1766)
de réir: Jean-Pierre Aguilar, et al.
Foilsithe / Cruthaithe: (2011-09-01)

Localization of tub and uncoupling proteins (Ucp) 2 and 3 to a region of rat chromosome 1 linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) type 2 diabetic rat.
de réir: Kaisaki, P, et al.
Foilsithe / Cruthaithe: (1998)

Uncoupling proteins 2 and 3 (UCP2/3) map to a region linked to glucose intolerance and adiposity in the Goto-Kakizaki (GK) diabetic rat
de réir: Kaisaki, P, et al.
Foilsithe / Cruthaithe: (1998)

Comparative analysis of biology and ecology of Glis glis (Gliridae, Rodentia) in the Zhiguli State Nature Reserve (Russia) and adjacent territories
de réir: Victoria A. Vekhnik
Foilsithe / Cruthaithe: (2020-01-01)

Marker-assisted congenic screening (MACS): a database tool for the efficient production and characterization of congenic lines.
de réir: Collins, S, et al.
Foilsithe / Cruthaithe: (2003)

Mutations in seipin are unlikely to cause diabetes in the goto-kakizaki (GK) diabetic rat
de réir: Kaisaki, P, et al.
Foilsithe / Cruthaithe: (2002)

Influence of internet usage on social and subjective well-being of Sri Lankan GLIS
de réir: Wickramasinghe, C. Nalaka, et al.
Foilsithe / Cruthaithe: (2013)