Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons

Molecular genetics of the transcription factor GLIS3 identifies its dual function in beta cells and neurons

The GLIS family zinc finger 3 isoform (GLIS3) is a risk gene for Type 1 and Type 2 diabetes, glaucoma and Alzheimer's disease endophenotype. We identified GLIS3 binding sites in insulin secreting cells (INS1) (FDR q<0.05; enrichment range 1.40-9.11 fold) sharing the motif wrGTTCCCArTAGs,...

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Detalles Bibliográficos
Main Authors: Calderari, S, Ria, M, Gérard, C, Nogueira, T, Villate, O, Collins, S, Neil, H, Gervasi, N, Hue, C, Suarez-Zamorano, N, Prado, C, Cnop, M, Bihoreau, M, Kaisaki, P, Cazier, J, Julier, C, Lathrop, M, Werner, M, Eizirik, D, Gauguier, D
Formato: Journal article
Idioma:English
Publicado: Elsevier 2018

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