Inhibitors of both the N-methyl lysyl- and arginyl- demethylase activities of the JmjC oxygenases
The Jumonji C (JmjC) family of 2-oxoglutarate (2OG) dependent oxygenases have established roles in the regulation of transcription via the catalysis of demethylation of Nε-methylated lysine residues in histone tails, especially the N-terminal tail of histone H3. Most human JmjC KDMs are complex enzy...
| Hoofdauteurs: | , , , |
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| Formaat: | Journal article |
| Gepubliceerd in: |
Royal Society
2018
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