The selective CCK-B receptor antagonist L-365,260 enhances morphine analgesia and prevents morphine tolerance in the rat.

The effects of the selective CCK-A antagonist L-365,031 and the selective CCK-B antagonist L-365,260 on morphine analgesia and opiate tolerance and dependence in rats were examined. L-365,031 and L-365,260 had no effect on baseline pain thresholds in the radiant heat tail flick test but enhanced ana...

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Bibliographic Details
Main Authors: Dourish, C, O'Neill, M, Coughlan, J, Kitchener, S, Hawley, D, Iversen, S
Format: Journal article
Language:English
Published: 1990