The type of somatic mutation at APC in familial adenomatous polyposis is determined by the site of the germline mutation: a new facet to Knudson's 'two-hit' hypothesis.

Lignende værker

• Evidence for genetic predisposition to desmoid tumours in familial adenomatous polyposis independent of the germline APC mutation.
  af: Sturt, N, et al.
  Udgivet: (2004)
• The adenomatous polyposis coli (APC) tumour suppressor--genetics, function and disease.
  af: Sieber, O, et al.
  Udgivet: (2000)
• Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis.
  af: Groves, C, et al.
  Udgivet: (2002)
• Molecular analysis of APC mutations in familial adenomatous polyposis and sporadic colon carcinomas.
  af: Cottrell, S, et al.
  Udgivet: (1992)
• Analysis of chromosomal instability in human colorectal adenomas with two mutational hits at APC.
  af: Sieber, O, et al.
  Udgivet: (2002)