Two mutations in human cardiac troponin I known to cause hypertrophic cardiomyopathy have different effects on cardiac muscle contraction

Geahča maid

• Effects of hypertrophic cardiomyopathy mutations in troponin I on contractility of skinned cardiac muscle fibres
  Dahkki: Burton, D, et al.
  Almmustuhtton: (2002)
• Two mutations in troponin I that cause hypertrophic cardiomyopathy have contrasting effects on cardiac muscle contractility.
  Dahkki: Burton, D, et al.
  Almmustuhtton: (2002)
• Altered inhibitory and troponin C-binding activities in cardiac troponin I mutants known to cause hypertrophic cardiomyopathy
  Dahkki: Elliott, K, et al.
  Almmustuhtton: (2000)
• A troponin I mutant known to cause hypertrophic cardiomyopathy shows reduced inhibition of Ca2+ independent tension
  Dahkki: Burton, D, et al.
  Almmustuhtton: (2000)
• Dilated and hypertrophic cardiomyopathy mutations in troponin and alpha-tropomyosin have opposing effects on the calcium affinity of cardiac thin filaments.
  Dahkki: Robinson, P, et al.
  Almmustuhtton: (2007)