Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.

Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent.

Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether this association is mediated through shared genetic or environmental factors...

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Main Authors: Guo, Y, Warren Andersen, S, Shu, X, Michailidou, K, Bolla, M, Wang, Q, Garcia-Closas, M, Milne, R, Schmidt, M, Chang-Claude, J, Dunning, A, Bojesen, S, Ahsan, H, Aittomäki, K, Andrulis, I, Anton-Culver, H, Arndt, V, Beckmann, M, Beeghly-Fadiel, A, Benitez, J, Bogdanova, N, Bonanni, B, Børresen-Dale, A, Brand, J, Brauch, H, Brenner, H, Brüning, T, Burwinkel, B, Casey, G, Chenevix-Trench, G, Couch, F, Cox, A, Cross, S, Czene, K, Devilee, P, Dörk, T, Dumont, M, Fasching, P, Figueroa, J, Flesch-Janys, D, Fletcher, O, Flyger, H, Fostira, F, Gammon, M, Giles, G, Guénel, P, Haiman, C, Hamann, U, Hooning, M, Hopper, J, Jakubowska, A, Jasmine, F, Jenkins, M, John, E, Johnson, N, Jones, M, Kabisch, M, Kibriya, M, Knight, J, Koppert, L, Kosma, V, Kristensen, V, Le Marchand, L, Lee, E, Li, J, Lindblom, A, Luben, R, Lubinski, J, Malone, K, Mannermaa, A, Margolin, S, Marme, F, McLean, C, Meijers-Heijboer, H, Meindl, A, Neuhausen, S, Nevanlinna, H, Neven, P, Olson, J, Perez, J, Perkins, B, Peterlongo, P, Phillips, K, Pylkäs, K, Rudolph, A, Santella, R, Sawyer, E, Schmutzler, R, Seynaeve, C, Shah, M, Shrubsole, M, Southey, M, Swerdlow, A, Toland, A, Tomlinson, I, Torres, D, Truong, T, Ursin, G, Van Der Luijt, R, Verhoef, S, Whittemore, A, Winqvist, R, Zhao, H, Zhao, S, Hall, P, Simard, J, Kraft, P, Pharoah, P, Hunter, D, Easton, D, Zheng, W
Format: Journal article
Language:English
Published: Public Library of Science 2016

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