Two-factor authentication underpins the precision of the piRNA pathway

Two-factor authentication underpins the precision of the piRNA pathway

The PIWI-interacting RNA (piRNA) pathway guides the DNA methylation of young, active transposons during germline development in male mice1. piRNAs tether the PIWI protein MIWI2 (PIWIL4) to the nascent transposon transcript, resulting in DNA methylation through SPOCD1 (refs. 2–5). Transposon methylat...

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Bibliographic Details
Main Authors: Dias Mirandela, M, Zoch, A, Leismann, J, Webb, S, Berrens, RV, Valsakumar, D, Kabayama, Y, Auchynnikava, T, Schito, M, Chowdhury, T, MacLeod, D, Xiang, X, Zou, J, Rappsilber, J, Allshire, RC, Voigt, P, Cook, AG, Barau, J, O’Carroll, D
Format: Journal article
Language:English
Published: Nature Research 2024

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