Scalable synthesis of (R,R)-N,N-dibenzyl-2-fluorocyclohexan-1-amine with CsF under hydrogen bonding phase-transfer catalysis
Hydrogen bonding phase-transfer catalysis offers a convenient solution to activate safe and economical metal alkali fluorides for enantioselective nucleophilic fluorination. Herein, we demonstrate the scalability of this protocol with the fluorination of 200 g of racemic trans-N,N-dibenzyl-2-bromocy...
| Hoofdauteurs: | , , , , , , , , |
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| Formaat: | Journal article |
| Taal: | English |
| Gepubliceerd in: |
American Chemical Society
2021
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