Scalable synthesis of (R,R)-N,N-dibenzyl-2-fluorocyclohexan-1-amine with CsF under hydrogen bonding phase-transfer catalysis

Scalable synthesis of (R,R)-N,N-dibenzyl-2-fluorocyclohexan-1-amine with CsF under hydrogen bonding phase-transfer catalysis

Hydrogen bonding phase-transfer catalysis offers a convenient solution to activate safe and economical metal alkali fluorides for enantioselective nucleophilic fluorination. Herein, we demonstrate the scalability of this protocol with the fluorination of 200 g of racemic trans-N,N-dibenzyl-2-bromocy...

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Bibliographic Details
Main Authors:	Vicini, AC, Alozie, D-M, Courtes, P, Roagna, G, Aubert, C, Certal, V, El-Ahmad, Y, Roy, S, Gouverneur, V
Format:	Journal article
Language:	English
Published:	American Chemical Society 2021

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