PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.

PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.

p73 has been identified as a structural and functional homolog of the tumor suppressor p53. The transcriptional coactivator Yes-associated protein (YAP) has been demonstrated to interact with and to enhance p73-dependent apoptosis in response to DNA damage. Here, we show the existence of a proapopto...

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Hlavní autoři: Lapi, E, Di Agostino, S, Donzelli, S, Gal, H, Domany, E, Rechavi, G, Pandolfi, P, Givol, D, Strano, S, Lu, X, Blandino, G
Médium: Journal article
Jazyk:English
Vydáno: 2008

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