PML, YAP, and p73 are components of a proapoptotic autoregulatory feedback loop.

p73 has been identified as a structural and functional homolog of the tumor suppressor p53. The transcriptional coactivator Yes-associated protein (YAP) has been demonstrated to interact with and to enhance p73-dependent apoptosis in response to DNA damage. Here, we show the existence of a proapopto...

Disgrifiad llawn

Manylion Llyfryddiaeth
Prif Awduron: Lapi, E, Di Agostino, S, Donzelli, S, Gal, H, Domany, E, Rechavi, G, Pandolfi, P, Givol, D, Strano, S, Lu, X, Blandino, G
Fformat: Journal article
Iaith:English
Cyhoeddwyd: 2008