Glucocorticoids induce senescence in primary human tenocytes by inhibition of sirtuin 1 and activation of the p53/p21 pathway: In vivo and in vitro evidence

Cellular senescence is an irreversible side effect of some pharmaceuticals which can contribute to tissue degeneration. Objective To determine whether pharmaceutical glucocorticoids induce senescence in tenocytes. Methods Features of senescence (β-galactosidase activity at pH 6 (SA-β-gal) and active...

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Bibliografski detalji
Glavni autori: Poulsen, R, Watts, A, Murphy, R, Snelling, S, Carr, A, Hulley, P
Format: Journal article
Jezik:English
Izdano: BMJ Publishing Group 2014