TRIM5α restricts poxviruses and is antagonized by CypA and viral protein C6
Human tripartite motif protein 5a (TRIM5α) is a well-characterised restriction factor for some RNA viruses including HIV, but against DNA viruses reports are limited. Here, we demonstrate TRIM5α also restricts orthopoxviruses and, via its SPRY domain, binds the orthopoxvirus capsid protein L3 to dim...
| Main Authors: | , , , , , |
|---|---|
| Format: | Journal article |
| Language: | English |
| Published: |
Springer Nature
2023
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