Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells

Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T-cells

Planar supported lipid bilayers (PSLBs) presenting T cell receptor (TCR) ligands and ICAM-1 induce budding of extracellular microvesicles enriched in functional TCR, defined here as synaptic ectosomes (SE), from helper T cells. SE bind peptide-MHC directly exporting TCR into the synaptic cleft, but...

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Bibliographic Details
Main Authors: Saliba, D, Cespedes-Donoso, P, Štefan Bálint, Š, Compeer, E, Korobchevskaya, K, Valvo, S, Mayya, V, Kvalvaag, A, Peng, Y, Dong, T, Tognoli, M, O'Neill, E, Bonham, S, Fischer, R, Kessler, B, Dustin, M
Format: Journal article
Language:English
Published: eLife Sciences Publications 2019

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