Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic beta cells

The molecular mechanisms underpinning GWAS loci for type 2 diabetes (T2D) remain poorly understood. Coding variants in peptidylglycine alpha-amidating monooxygenase (PAM) are associated with both T2D risk and insulinogenic index. Here, we demonstrate that the T2D risk alleles impact negatively on ov...

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Bibliographic Details
Main Authors:	Thomsen, S, Raimondo, A, Hastoy, B, Sengupta, S, Dai, X, Bautista, A, Censin, J, Payne, A, Umapathysivam, M, Spigelman, A, Barrett, A, Groves, C, Beer, N, Manning Fox, J, McCarthy, M, Clark, A, Mahajan, A, Rorsman, O, MacDonald, P, Gloyn, A
Format:	Journal article
Published:	Nature Publishing Group 2018

Type 2 diabetes risk alleles in PAM impact insulin release from human pancreatic beta cells

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