Happy mapping: a proposal for linkage mapping the human genome.
A theoretical approach for linkage mapping the genome of any higher eukaryote is described. It uses the polymerase chain reaction, oligonucleotides of random sequence and single haploid cells. Markers are defined and then the DNA of a single sperm is broken at random (eg by gamma-rays) and physicall...
| Main Authors: | , |
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| Format: | Journal article |
| Language: | English |
| Published: |
1989
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