Fast measurement of sarcomere length and cell orientation in Langendorff-perfused hearts using remote focusing microscopy.

RATIONALE: Sarcomere length (SL) is a key indicator of cardiac mechanical function, but current imaging technologies are limited in their ability to unambiguously measure and characterize SL at the cell level in intact, living tissue. OBJECTIVE: We developed a method for measuring SL and regional ce...

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Bibliographic Details
Main Authors: Botcherby, E, Corbett, A, Burton, R, Smith, C, Bollensdorff, C, Booth, M, Kohl, P, Wilson, T, Bub, G
Format: Journal article
Language:English
Published: 2013