An autonomous oscillation times and executes centriole biogenesis

The accurate timing and execution of organelle biogenesis is crucial for cell physiology. Centriole biogenesis is regulated by Polo-like kinase 4 (Plk4) and initiates in S-phase when a daughter centriole grows from the side of a pre-existing mother. Here, we show that a Plk4 oscillation at the base...

Full description

Bibliographic Details
Main Authors: Aydogan, MG, Steinacker, TL, Mofatteh, M, Wilmott, ZM, Zhou, FY, Gartenmann, L, Wainman, A, Saurya, S, Novak, ZA, Wong, SS, Goriely, A, Boemo, MA, Raff, JW
Format: Journal article
Language:English
Published: Elsevier 2020