Are experimental treatments for cancer in children superior to established treatments? Observational study of randomised controlled trials by the Children's Oncology Group.

OBJECTIVES: To assess how often new treatments for childhood cancer assessed in phase III randomised trials are superior or inferior to standard treatments and whether the pattern of successes and failures in new treatments is consistent with uncertainty being the ethical basis for enrolling patient...

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Main Authors: Kumar, A, Soares, H, Wells, R, Clarke, M, Hozo, I, Bleyer, A, Reaman, G, Chalmers, I, Djulbegovic, B
格式: Journal article
语言:English
出版: 2005