MHC-peptide-specific antibodies reveal inefficient presentation of an HLA-A*0201-restricted, Melan-A-derived peptide after active intracellular processing.

MHC-peptide-specific Fab antibodies binding to HLA-A*0201 complexes presenting the wild-type EAAGIGILTV (EAA) or analogue Melan-A 10-mer ELAGIGILTV (ELA) peptide were generated to study efficacy of peptide processing and presentation. None of the selected Fab antibodies detected the naturally proces...

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Bibliographic Details
Main Authors: Held, G, Wadle, A, Dauth, N, Stewart-Jones, G, Sturm, C, Thiel, M, Zwick, C, Dieckmann, D, Schuler, G, Hoogenboom, H, Lévy, F, Cerundolo, V, Pfreundschuh, M, Renner, C
Format: Journal article
Language:English
Published: 2007