A highly efficient human pluripotent stem cell microglia model displays a neuronal-co-culture-specific expression profile and inflammatory response

Microglia are increasingly implicated in brain pathology, particularly neurodegenerative disease, with many genes implicated in Alzheimer's, Parkinson's, and motor neuron disease expressed in microglia. There is, therefore, a need for authentic, efficient in vitro models to study human mic...

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Hlavní autoři: Haenseler, W, Sansom, S, Buchrieser, J, Newey, S, Moore, C, Nicholls, F, Chintawar, S, Schnell, C, Antel, J, Allen, N, Cader, M, Wade-Martins, R, James, W, Cowley, S
Médium: Journal article
Jazyk:English
Vydáno: Cell Press 2017