Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.

Contribution of the central hydrophobic residue in the PXP motif of voltage-dependent K+ channels to S6 flexibility and gating properties.

Shaker-like (KV1.1) channels contain a highly conserved Pro-Val-Pro (PVP) motif at the base of S6 that produces a kink in the S6 helices and provides a flexible element thought to be essential for channel gating. The role of proline-induced kinks in transmembrane helices is well known, but the contr...

Полное описание

Библиографические подробности
Главные авторы:	Imbrici, P, Grottesi, A, D'Adamo, M, Mannucci, R, Tucker, S, Pessia, M
Формат:	Journal article
Язык:	English
Опубликовано:	2009

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