The potential for repurposing anti-TNF as a therapy for the treatment of COVID-19
Coronavirus disease 2019 (COVID-19) currently has few effective treatments. Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important that the search for treatments continue. An exaggerated inflammatory state is likely responsible for much of the morbidity and mort...
| Main Authors: | , , , , , , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2020
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| _version_ | 1826277910988718080 |
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| author | Robinson, PC Liew, DFL Liew, JW Monaco, C Richards, D Shivakumar, S Tanner, HL Feldmann, M |
| author_facet | Robinson, PC Liew, DFL Liew, JW Monaco, C Richards, D Shivakumar, S Tanner, HL Feldmann, M |
| author_sort | Robinson, PC |
| collection | OXFORD |
| description | Coronavirus disease 2019 (COVID-19) currently has few effective treatments. Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important that the search for treatments continue. An exaggerated inflammatory state is likely responsible for much of the morbidity and mortality in COVID-19. Elevated levels of tumor necrosis factor (TNF), a key pro-inflammatory cytokine, have been shown to be associated with increased COVID-19 mortality. In patients with rheumatoid arthritis, TNF blockade reduces not only biologically active TNF but other pro-inflammatory cytokines important in COVID-19 hyperinflammation. Observational data from patients already on anti-TNF therapy show a reduced rate of COVID-19 poor outcomes and death compared with other immune-suppressing therapies. Anti-TNF has a long history of safe use, including in special at-risk populations, and is widely available. The case to adequately assess anti-TNF as a treatment for COVID-19 is compelling. |
| first_indexed | 2024-03-06T23:36:01Z |
| format | Journal article |
| id | oxford-uuid:6daff309-76ae-4f94-bc4b-92fd6a8944c1 |
| institution | University of Oxford |
| language | English |
| last_indexed | 2024-03-06T23:36:01Z |
| publishDate | 2020 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | oxford-uuid:6daff309-76ae-4f94-bc4b-92fd6a8944c12022-03-26T19:19:30ZThe potential for repurposing anti-TNF as a therapy for the treatment of COVID-19Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6daff309-76ae-4f94-bc4b-92fd6a8944c1EnglishSymplectic ElementsElsevier2020Robinson, PCLiew, DFLLiew, JWMonaco, CRichards, DShivakumar, STanner, HLFeldmann, MCoronavirus disease 2019 (COVID-19) currently has few effective treatments. Given the uncertainty surrounding the effectiveness and uptake of a vaccine, it is important that the search for treatments continue. An exaggerated inflammatory state is likely responsible for much of the morbidity and mortality in COVID-19. Elevated levels of tumor necrosis factor (TNF), a key pro-inflammatory cytokine, have been shown to be associated with increased COVID-19 mortality. In patients with rheumatoid arthritis, TNF blockade reduces not only biologically active TNF but other pro-inflammatory cytokines important in COVID-19 hyperinflammation. Observational data from patients already on anti-TNF therapy show a reduced rate of COVID-19 poor outcomes and death compared with other immune-suppressing therapies. Anti-TNF has a long history of safe use, including in special at-risk populations, and is widely available. The case to adequately assess anti-TNF as a treatment for COVID-19 is compelling. |
| spellingShingle | Robinson, PC Liew, DFL Liew, JW Monaco, C Richards, D Shivakumar, S Tanner, HL Feldmann, M The potential for repurposing anti-TNF as a therapy for the treatment of COVID-19 |
| title | The potential for repurposing anti-TNF as a therapy for the treatment of COVID-19 |
| title_full | The potential for repurposing anti-TNF as a therapy for the treatment of COVID-19 |
| title_fullStr | The potential for repurposing anti-TNF as a therapy for the treatment of COVID-19 |
| title_full_unstemmed | The potential for repurposing anti-TNF as a therapy for the treatment of COVID-19 |
| title_short | The potential for repurposing anti-TNF as a therapy for the treatment of COVID-19 |
| title_sort | potential for repurposing anti tnf as a therapy for the treatment of covid 19 |
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