Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding.

DRP-1 is a pro-apoptotic Ca2+/calmodulin (CaM)-regulated serine/threonine kinase, recently isolated as a novel member of the DAP-kinase family of proteins. It contains a short extra-catalytic tail required for homodimerization. Here we identify a novel regulatory mechanism that controls its pro-apop...

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Bibliographic Details
Main Authors: Shani, G, Henis-Korenblit, S, Jona, G, Gileadi, O, Eisenstein, M, Ziv, T, Admon, A, Kimchi, A
Format: Journal article
Language:English
Published: 2001