Enantioselective desymmetrisation of an epoxytropinone for peduncularine synthesis
A key 7-allyl-8-hydroxy-6-azabicyclo[3.2.1]octan-3-one intermediate in a synthesis of the alkaloid peduncularine is obtained enantioenriched, by desymmetrisation of an achiral 6,7-epoxy-8-azabicyclo[3.2.1]octan-3-one (epoxytropinone). Chiral lithium amide-assisted enantioselective silyl enol ether f...
| Main Authors: | , , |
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| Format: | Journal article |
| Language: | English |
| Published: |
Elsevier
2020
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