Effects of alteplase for acute stroke according to criteria defining the EU and US marketing authorizations: individual-patient-data meta-analysis of randomized trials

<p>Background: The recommended maximum age and time window for intravenous alteplase treatment of acute ischemic stroke (AIS) each differ between Europe (EU) and United States (US). </p><p> Aims: To compare the effects of alteplase according to cohorts defined by current EU or US...

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Main Authors: Hacke, W, Lyden, P, Emberson, J, Baigent, C, Blackwell, L, Albers, G, Bluhmki, E, Brott, T, Cohen, G, Davis, SM, Donnan, GA, Grotta, JC, Howard, G, Kaste, M, Koga, M, von Kummer, R, Lansberg, MG, Lindley, RI, Olivot, J-M, Parsons, M, Sandercock, PAG, Toni, D, Toyoda, K, Wahlgren, N, Wardlaw, JM, Whiteley, WN, del Zoppo, G, Lees, KR
Format: Journal article
Published: SAGE Publications 2017