Targeting the nucleus: an overview of Auger-electron radionuclide therapy.

The review presented here lays out the present state of the art in the field of radionuclide therapies specifically targeted against the nucleus of cancer cells, focussing on the use of Auger-electron-emitters. Nuclear localisation of radionuclides increases DNA damage and cell kill, and, in the cas...

Ամբողջական նկարագրություն

Մատենագիտական մանրամասներ
Հիմնական հեղինակներ: Cornelissen, B, Vallis, K
Ձևաչափ: Journal article
Լեզու:English
Հրապարակվել է: 2010
_version_ 1826277999787376640
author Cornelissen, B
Vallis, K
author_facet Cornelissen, B
Vallis, K
author_sort Cornelissen, B
collection OXFORD
description The review presented here lays out the present state of the art in the field of radionuclide therapies specifically targeted against the nucleus of cancer cells, focussing on the use of Auger-electron-emitters. Nuclear localisation of radionuclides increases DNA damage and cell kill, and, in the case of Auger-electron therapy, is deemed necessary for therapeutic effect. Several strategies will be discussed to direct radionuclides to the nucleoplasm, even to specific protein targets within the nucleus. An overview is given of the applications of Auger-electron-emitting radionuclide therapy targeting the nucleus. Finally, a few suggestions are made as how radioimmunotherapy with nuclear targets can be improved, and the challenges that might be met, such as how to perform accurate dosimetry measurements, are examined.
first_indexed 2024-03-06T23:37:22Z
format Journal article
id oxford-uuid:6e1e1ca2-dfb5-406d-8e4f-445c1a4d24f6
institution University of Oxford
language English
last_indexed 2024-03-06T23:37:22Z
publishDate 2010
record_format dspace
spelling oxford-uuid:6e1e1ca2-dfb5-406d-8e4f-445c1a4d24f62022-03-26T19:22:15ZTargeting the nucleus: an overview of Auger-electron radionuclide therapy.Journal articlehttp://purl.org/coar/resource_type/c_dcae04bcuuid:6e1e1ca2-dfb5-406d-8e4f-445c1a4d24f6EnglishSymplectic Elements at Oxford2010Cornelissen, BVallis, KThe review presented here lays out the present state of the art in the field of radionuclide therapies specifically targeted against the nucleus of cancer cells, focussing on the use of Auger-electron-emitters. Nuclear localisation of radionuclides increases DNA damage and cell kill, and, in the case of Auger-electron therapy, is deemed necessary for therapeutic effect. Several strategies will be discussed to direct radionuclides to the nucleoplasm, even to specific protein targets within the nucleus. An overview is given of the applications of Auger-electron-emitting radionuclide therapy targeting the nucleus. Finally, a few suggestions are made as how radioimmunotherapy with nuclear targets can be improved, and the challenges that might be met, such as how to perform accurate dosimetry measurements, are examined.
spellingShingle Cornelissen, B
Vallis, K
Targeting the nucleus: an overview of Auger-electron radionuclide therapy.
title Targeting the nucleus: an overview of Auger-electron radionuclide therapy.
title_full Targeting the nucleus: an overview of Auger-electron radionuclide therapy.
title_fullStr Targeting the nucleus: an overview of Auger-electron radionuclide therapy.
title_full_unstemmed Targeting the nucleus: an overview of Auger-electron radionuclide therapy.
title_short Targeting the nucleus: an overview of Auger-electron radionuclide therapy.
title_sort targeting the nucleus an overview of auger electron radionuclide therapy
work_keys_str_mv AT cornelissenb targetingthenucleusanoverviewofaugerelectronradionuclidetherapy
AT vallisk targetingthenucleusanoverviewofaugerelectronradionuclidetherapy