Independent function of two destruction domains in hypoxia-inducible factor-alpha chains activated by prolyl hydroxylation.

Oxygen-dependent proteolytic destruction of hypoxia-inducible factor-alpha (HIF-alpha) subunits plays a central role in regulating transcriptional responses to hypoxia. Recent studies have defined a key function for the von Hippel-Lindau tumour suppressor E3 ubiquitin ligase (VHLE3) in this process,...

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Detaylı Bibliyografya
Asıl Yazarlar: Masson, N, Willam, C, Maxwell, P, Pugh, C, Ratcliffe, P
Materyal Türü: Journal article
Dil:English
Baskı/Yayın Bilgisi: 2001