Variation in genes coding for AMP-activated protein kinase (AMPK) and breast cancer risk in the European Prospective Investigation on Cancer (EPIC).

AMP-activated protein kinase (AMPK) is an energy sensing/signalling intracellular protein which is activated by an increase in the cellular AMP:ATP ratio after ATP depletion. Once activated, AMPK inhibits fatty acid synthesis and the Akt-mTOR pathway, and activates the p53-p21 axis. All these molecu...

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Bibliographic Details
Main Authors: Campa, D, Claus, R, Dostal, L, Stein, A, Chang-Claude, J, Meidtner, K, Boeing, H, Olsen, A, Tjønneland, A, Overvad, K, Rodríguez, L, Bonet, C, Sánchez, M, Amiano, P, Huerta, J, Barricarte, A, Khaw, K, Wareham, N, Travis, R, Allen, N, Trichopoulou, A, Bamia, C, Benetou, V, Palli, D, Agnoli, C
Format: Journal article
Language:English
Published: 2011