Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor.

We have mapped a Jagged/Serrate-binding site to specific residues within the 12th EGF domain of human and Drosophila Notch. Two critical residues, involved in a hydrophobic interaction, provide a ligand-binding platform and are adjacent to a Fringe-sensitive residue that modulates Notch activity. Ou...

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Bibliographic Details
Main Authors:	Whiteman, P, de Madrid, B, Taylor, P, Li, D, Heslop, R, Viticheep, N, Tan, J, Shimizu, H, Callaghan, J, Masiero, M, Li, J, Banham, A, Harris, A, Lea, S, Redfield, C, Baron, M, Handford, P
Format:	Journal article
Language:	English
Published:	2013

Molecular basis for Jagged-1/Serrate ligand recognition by the Notch receptor.

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