Metastability of native proteins and the phenomenon of amyloid formation.

An experimental determination of the thermodynamic stabilities of a series of amyloid fibrils reveals that this structural form is likely to be the most stable one that protein molecules can adopt even under physiological conditions. This result challenges the conventional assumption that functional...

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Bibliographic Details
Main Authors: Baldwin, A, Knowles, T, Tartaglia, G, Fitzpatrick, A, Devlin, G, Shammas, S, Waudby, C, Mossuto, M, Meehan, S, Gras, S, Christodoulou, J, Anthony-Cahill, S, Barker, P, Vendruscolo, M, Dobson, C
Format: Journal article
Language:English
Published: 2011